New breast cancer drug found to boost survival rates by 30 percent
A new form of drug drastically improves survival rates of pre-menopausal women with the most common type of breast cancer, researchers have said, citing the results of an international clinical trial.
The findings, presented at the annual meeting of the American Society of Clinical Oncology in Chicago, showed that the addition of cell-cycle inhibitor ribociclib increased survival rates to 70 percent after three and a half years.
The mortality rate was 29 percent less than when patients were randomly assigned a placebo.
Lead author Sara Hurvitz told AFP the study focused on hormone receptor-positive breast cancer, which accounts for two-thirds of all breast cancer cases among younger women and is generally treated by therapies that block estrogen production.
The treatment is less toxic than traditional chemotherapy because it more selectively targets cancerous cells, blocking their ability to multiply.
An estimated 268,000 new cases of breast cancer are expected to be diagnosed in women in the U.S. in 2019, while the advanced form of the disease is the leading cause of cancer deaths among women aged 20 to 59.
“These are patients who tend to be diagnosed later, at a later stage in their disease, because we don’t have great screening modalities for young women,” said Hurvitz.
“That’s what makes us so excited, because it’s a therapy that’s affecting so many patients with advanced disease,” added Hurvitz.
A pill is administered daily for 21 days followed by seven days off to allow the body time to recover, since two-thirds of patients have a moderate to severe drop in white cell count.
Jamie Bennett, a spokeswoman for Novartis, which markets the drug under the brand name Kisqali and funded the research, said it cost $12,553 for a 28-day dose.
But, she added, “the majority of patients in the U.S. with commercial insurance will pay $0 per month for their Kisqali prescription.”
Oncologist Harold Burstein, who was not involved in the research, said it was “an important study,” having established that the use of cyclin inhibitors “translates into a significant survival benefit for women.”
Burstein is with the Dana-Farber Cancer Institute in Boston.
“Hopefully, these data will enable access for this product for more women around the world, particularly in healthcare systems which assess value rigorously as part of their decisions for national access to drugs,” Burstein added.
Moving forward, Hurvitz said she was interested in investigating whether ribociclib could help nip cancer in the bud at an earlier stage.
“We want to go and look at those women diagnosed with early stage disease, small tumors, tumors that haven’t gone to the lymph nodes or haven’t gone to other parts of the body and see if we can stop it from returning later from metastasizing,” she said.
A new global clinical trial is now underway.