Federer eyes 100th Wimbledon win and Nadal showdown
In a quarterfinal line-up which features five players over 30, there is a growing anticipation of a potential 40th career match-up between the sport's two most successful players.
If it does happen, it will be their first at the All England Club since 2008 when Nadal triumphed in what is widely regarded as the greatest final ever played at the tournament.
Whoever battles through that side of the draw is likely to find defending champion and four-time winner Novak Djokovic waiting in the final.
At 37, Federer is the oldest quarterfinalist since Jimmy Connors in 1991.
He reached his 17th quarterfinal at the All England Club, and 55th at the majors, with a 74-minute demolition of Italy's Matteo Berrettini, dropping just five games.
"I think the best guys now are fully engaged, they know exactly what to expect from the court and the conditions," said second seed Federer.
"That helps us to play better. I think with experience, that's good. We haven't dropped much energy in any way."
Federer will take a 7-3 record over seventh-seeded Nishikori into his quarterfinal.
Nishikori defeated the great Swiss in the ATP Finals last year, ending a drought which had stretched to almost five years.
"I think he's got one of the best backhands in the game. He's a great return player. Solid mentally. I always thought he was a great talent."
Querrey made the semifinals in 2017, beating then world number one Andy Murray in the last-eight before falling to Marin Cilic.
The American has pounded down 100 aces so far at the tournament, dropped serve just once and accounted for fifth seed Dominic Thiem in the first round.
Top seed Djokovic has a 5-1 record over his quarter-final opponent David Goffin who, at 28, is the youngest man left.
Belgian 21st seed Goffin beat Djokovic the last time they met in 2017 but that was on the clay of Monte Carlo.
"He's one of the quickest players on the tour. I think his footwork is probably his biggest asset," said Djokovic ahead of his 11th Wimbledon quarter-final and 45th at the Slams.
July 10y's other quarterfinal pits Argentine 26th seed Guido Pella, who had never previously got into the second week of a Slam, against Spanish 23rd seed Roberto Bautista Agut.
Whereas 29-year-old Pella is in unchartered territory, Bautista Agut is in his second Slam quarterfinal of the season having also gone to the last eight at the Australian Open.